Part of a terminal at the Charles de Gaulle airport in Paris collapsed on Sunday killing four people and injuring three others. A thirty foot section of the newly built £500 million Terminal 2E gave way without warning as flights from New York and Johannesburg were arriving and a flight bound for Prague was boarding. Eye witness reports said part of the roofing structure collapsed onto a walkway which in turn buckled, causing the disaster. Structural Engineer David Adams said, “The cause of this disaster is completely unknown and we are unlikely to get to the bottom of it if French bureaucracy plays its part.” The left-wing labour union CGT said it had issued warnings about the rush to complete the terminal after Air France raised commercial concerns. The Terminal was completed at the end of June of last year and was due to be extended in order to accommodate the new Airbus 380s. The future of the terminal is now in doubt as new cracks appeared affecting a fresh evacuation. The French authorities have stated that if the structure proves to be completely unsound demolition would be the only option available. This would be a devastating blow to Air France’s prestige project designed to bring Charles de Gaulle airport to the forefront of international air travel. Chief architect Paul Andreu has flown in to inspect the damage and has put himself at the disposal of the French authorities.ARCHIVE: 4th week TT 2004
Testing in miceThe group is also studying coronavirus immune responses in a living animal model.The first mice have already been inoculated with a similar coronavirus spike protein derived from the SARS-2003 coronavirus with or without a lead adjuvant combination to get an early read on measuring an antibody response.Several leading laboratories are providing essential input to the PVP in efforts to develop an effective, targeted coronavirus vaccine that works well for older individuals:Barney Graham, deputy director of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases (NIAID), provided the coronavirus spike protein to the PVP a few weeks ago.Florian Krammer at the Icahn School of Medicine at Mount Sinai provided SARS-CoV-2 virus from the current strain.Peter Hotez and Maria Bottazzi at Baylor University contributed antigen from the 2003 SARS outbreak.Lindsey Baden, director of clinical research at Brigham and Women’s Hospital, provided blood samples from elderly patients.Envisioning a seasonal coronavirus vaccineLooking ahead, the PVP is looking to create a vaccine platform and systematic program that would facilitate vaccine development in any future coronavirus outbreaks.“Dr. Anthony Fauci, director of the NIAID, has warned of the potential of SARS-CoV-2 to become a seasonal virus like flu,” said David Dowling, instructor in pediatrics at HMS and a member of the PVP. “If so, the biomedical community may need to consider developing a multivalent yearly seasonal vaccine effective against multiple coronaviruses.”As ongoing international surveillance identifies circulating coronavirus strains, the PVP envisions collaborating with other laboratories to obtain corresponding viral spike proteins and modeling responses of the elderly to different adjuvant/antigen combinations to determine which is most effective.Three COVID-19 vaccine conceptsLevy and Dowling estimate that more than 24 COVID-19 vaccine candidates are in development globally. These vaccines fall into three general types:RNA-based vaccines. The first COVID-19 vaccines in development have used SARS-CoV-2 RNA. “This approach is innovative and attractive, but even if proven effective it may be difficult to create hundreds of millions of doses, and each dose may be relatively expensive as it may require a fair amount of RNA,” said Dowling. “While there is less experience with human testing for this approach, it is possible that adjuvants may help enhance the immune response when such vaccines are administered to older populations and may reduce the amount of RNA needed in each vaccine.”DNA-based technology. Like RNA-based vaccines, this promising approach uses the genetic material of the virus to produce a vaccine. “You can make more vaccine doses with DNA than with RNA, but it is unclear whether the production could be rapidly scaled to meet the massive international demand,” said Dowling. “And, to our knowledge, these nucleic acid vaccines have not yet been tested in elderly patients either.”Building on earlier coronavirus vaccines. This is the approach PVP is taking: learning from earlier vaccines from prior coronavirus outbreaks and making them more effective. “If you add an adjuvant chosen specifically for optimal activity in an older population, not only does it work better in that group, but it may dramatically reduce the cost per vaccine dose by reducing the amount of antigen required,” said Dowling.Adapted from a post on Discoveries, the Boston Children’s research and clinical innovation blog. As the number of novel coronavirus infections rises daily across the globe, strategies for developing a safe and effective vaccine are rapidly moving forward.In response to this public health crisis, researchers in the Precision Vaccines Program (PVP) at Boston Children’s Hospital are on the front lines of developing a vaccine specially targeted toward older populations — those who are at greatest risk of developing coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-2 coronavirus (SARS-CoV-2).According to the World Health Organization, older people and people with preexisting medical conditions appear to be more vulnerable to becoming severely ill with COVID-19.“Elderly individuals have a different immune system than healthy middle-aged adults and often do not respond as robustly to immunization, so a one-size vaccine does not fit all,” said Ofer Levy, professor of pediatrics at Harvard Medical School and director of the PVP.Focusing on adjuvantsThe current antigen used for vaccine development is the coronavirus spike protein, so named because it sits atop the spike of a coronavirus particle. This is the part of the virus that the immune system “remembers.”Vaccine-induced antibodies, made by the immune system against the spike protein, can prevent infection.PVP’s strategy is to combine the coronavirus spike protein with adjuvants: small molecules added to a vaccine to boost the recipient’s immune response.“Overall, we are hoping that a precision adjuvant approach will assist the various ongoing vaccine efforts across the globe,” said Levy. “Adjuvants can be crucial for getting a stronger, longer-lasting, broader immune response, especially among those with weakened immunity, like the elderly.”The team’s approach is unusual in the range and novelty of adjuvants they will screen, said Levy.In addition to a collection of known vaccine adjuvants, the team will test new adjuvants it has discovered in the PVP’s National Institutes of Health-funded Adjuvant Discovery Program.“These adjuvants were discovered by screening against human cells,” said Levy. “This species-specific approach represents an example of precision vaccinology.”Age specificThe PVP plans on testing a variety of adjuvants and adjuvant combinations in human white blood cells sourced from older people. Researchers will then study the adjuvant-induced immune responses.“Our screen, comparing individual and combination adjuvants with and without the coronavirus antigen, will identify an adjuvant combination that most effectively induces an optimal immune response in the elderly,” Levy said. These screens will start immediately and continue over the next six to eight weeks.“We’re hoping to have a clear signal within the next few months which adjuvanted vaccine to go forward with in clinical testing,” he added.Typically, adjuvant-based vaccine research does not consider species or age in the discovery and early development phases.“Our use of age-specific human in vitro systems to de-risk and accelerate an adjuvanted vaccine tailored to the elderly is novel,” said Levy. “In this way, we are bringing precision medicine to vaccinology.”Adjuvants could also be a cost-saving strategy, the authors said, because the antigen is typically the most expensive part of a vaccine.“If we want to be able to provide billions of vaccine doses, adjuvants can be the answer as they enhance the immune system so much less antigen is needed to get a protective immune response,” said Levy. “Elderly individuals have a different immune system than healthy middle-aged adults and often do not respond as robustly to immunization, so a one-size vaccine does not fit all.” — Ofer Levy, Harvard Medical School
The footballers play Roscommon on the football qualifiers in Galway on Saturday while the hurlers face Galway in the All Ireland quarter final on Sunday
â€“â€“â€“â€“â€“ By Tracy McCue, Sumner Newscow â€” The following are the garage sales that we have for the Sept. 4 weekend. If you still need a garage sale advertised just use the comment section below. Good luck with bargain hunting!Â Follow us on Twitter. Close Forgot password? Please put in your email: Send me my password! Close message Login This blog post All blog posts Subscribe to this blog post’s comments through… RSS Feed Subscribe via email Subscribe Subscribe to this blog’s comments through… RSS Feed Subscribe via email Subscribe Follow the discussion Comments (10) Logging you in… Close Login to IntenseDebate Or create an account Username or Email: Password: Forgot login? Cancel Login Close WordPress.com Username or Email: Password: Lost your password? Cancel Login Dashboard | Edit profile | Logout Logged in as Admin Options Disable comments for this page Save Settings Sort by: Date Rating Last Activity Loading comments… You are about to flag this comment as being inappropriate. Please explain why you are flagging this comment in the text box below and submit your report. The blog admin will be notified. Thank you for your input. +1 Vote up Vote down CueballSumnernewscow 94p · 258 weeks ago OK, gang, this is all you have to do. Write up your garage sale and submit it as a comment. Write as much as you like and you won’t pay one cent! Example: Joe Blow at 100 North New York Avenue is having a garage sale for the Wellington Citywide. We will start the sale at 6 a.m. and run through noon Saturday. We will be offering a variety of stuff including clothes, furniture and a beautiful hand-woven rug. We will also be giving out free lemonade. Call us at 888-888-8888 if your have any questions. Hope to see you there! Report Reply 0 replies · active 258 weeks ago 0 Vote up Vote down Time to sell · 258 weeks ago Garage & Yard sale at 1010 E. 8th. The sale will start on Friday, Sept. 4th from 3-7pm and Saturday, Sept. 5th from 8am-1pm. There will be a variety of awesome stuff including furniture, home decorating items, clothing, something for everyone! Items will be priced to sell. Report Reply 0 replies · active 258 weeks ago -1 Vote up Vote down Almost free · 258 weeks ago Garage sale at 824 West Lincoln Saturday Sept. 5th from 8am-12pm. Furniture and décor, large variety from bathroom furnishings vanities, mirrors and lights. Dixon riding mower, tools, dog kennel panels and lots of other items selling cheap. Report Reply 0 replies · active 258 weeks ago 0 Vote up Vote down Carolyn Heasty · 258 weeks ago Large Yard Sale Saturday September 12. 8 a.m. to 3 p.m.. 1430 N. Day, We have lots of seasonal decorations, yard art, dishware, furniture, and lots of Miscellaneous. Report Reply 0 replies · active 258 weeks ago 0 Vote up Vote down Sandy Cobb · 258 weeks ago Yard Sale,Thursday 9-3-15, 515 N. Jefferson, 8 am – 5 pm. Scissor style push mower, 2 electric weed eaters, outside folding chairs, vintage chest of drawers, vacuum sweeper, some name brand Jr. girl clothes, household items, & lots stuff. Very reasonable. We want it to be gone! Report Reply 0 replies · active 258 weeks ago +2 Vote up Vote down Tiffany · 258 weeks ago Garage sale 1615 North C St Wellington Friday 8am-?? and Saturday 8am -??. Baby girl clothes up to 24 months both seasons, Medela breast pump, other misc baby items, computer desk, monitor, keyboard, mouse, and speakers adding more I as I go through stuff. Report Reply 0 replies · active 258 weeks ago 0 Vote up Vote down Sandy Cobb · 258 weeks ago Yard Sale, Friday, 9-4-15, 515 N. Jefferson, Wellington, 8:00 am – 11:00 am. What’s left sale. electric weed eater, 2 red folding yard chairs, boat chairs, pool liner & pump, end table, small appliances, nice Jr. girls clothes, & misc. stuff. Let’s be done prices. Report Reply 0 replies · active 258 weeks ago 0 Vote up Vote down amanda · 257 weeks ago Garage sale Friday 3-7 Saturday 8-1 address is 1010 E 8th Something for everyone 🙂 Report Reply 0 replies · active 257 weeks ago 0 Vote up Vote down Sandy Cobb · 257 weeks ago Attention !!! Whoever bought the tent in the box, at my yard sale, please come back. The most important thing is missing, the tent. I really want you to have it. 515 N. Jefferson Report Reply 0 replies · active 257 weeks ago 0 Vote up Vote down Olene · 251 weeks ago Yard Sale!! Saturday, October 24th. From 8 a.m. Till 3 p.m.. 1325 North Washington. We have seasonal decorations, glassware, books, and lots of miscellaneous items. Come and check it out! Report Reply 0 replies · active 251 weeks ago Post a new comment Enter text right here! 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AIR ATTACK – Ben Roethlisberger getting plenty of protection as he throws the ball. His stats are impressive but his production in the Red Zone has been very poor. (Photo by Julio Torres for New Pittsburgh Courier)After going down in defeat to the previously lowly Cleveland Browns, 31-10, now the Steelers must face three of the roughest teams in the NFL in the Houston Texans, 3-3, the Indianapolis Colts, 4-2 and the Baltimore Ravens, 4-2.If the Steelers don’t find a way to improve their offense and defense, they just may find themselves setting at the bottom of the tough AFC North at 3-6.They face the Texans this coming Monday Oct. 20 on ESPN Monday Night Football.Even though the Texans have some great offensive weapons in wide receiver Andre Johnson who is considered to be one of the best in the league and running back Arian Foster, who is also one of the best in the league they are questionable at quarterback.Ryan Fitzpatrick still hasn’t proven he can play with the big boys, having come from the Buffalo Bills. And when was the last time Buffalo had a winning team.But with Foster they don’t have to depend on the passing game. Foster gives them one of the best backs in the league. He had 109 yards on 20 carries in their most recent loss, 33-28 to the Colts. For the season he’s among the NFL leaders with 573 yards on 106 carries.But when they have to go to the air the Johnson boys give them two of the best receivers in the NFL. Andre has 34 catches for 449 yards, and DeAndre Johnson has 25 catches for 366 yards. Andre is a beast. In short they can score points. But their strength over the years has been their defense, and even though the Colts scored 33 punts on them, their strength is still their defense.The Steelers will have to work for everything they get and will have to score 20 or more points to beat this team.Last weekend the Browns beat the Steelers in every aspect of the game to post the 31-10 victory, despite having terrible stats. The Steelers racked up the stats in passing and rushing but could not take the ball in for touchdowns when in the red zone.Brian Hoyer had only 217 yards passing going only 8 of 17 but Ben Tate had 78 yards on 25 carries on the ground and Isaiah Crowell had 77 on 11 carries. In comparison to Ben Roethlisberger who was 21 of 42 for 228 yards, Antonio Brown had 7 catches for 116 yards and Le’Veon Bell had 82 yards on 18 carries.The Steelers problem is play calling when they get in the red zone. They run when they should be passing and pass when they should be running. On second and short you use your big back, not trick plays. Blount is rarely in the game on short yardage and when he is they don’t use him. In their next three games the Steelers are going to have to score touchdowns and stop settling for field goals especially against the Colts and Ravens.At one time Andrew Luck was considered to be one of the best young quarterbacks in the league. Well now he’s one of the best in the league period. He was 25 of 44 for 370 yards and 3 touchdowns in the Colts win over the Texans and he has 1867 yards passing and 17 touchdown passes. He has two great receivers to pass to in Reggie Wayne 34 catches for 419 yards and T. Y. Hilton 40 catches for 604 yards. And they have a solid ground game with Ahmad Bradshaw, and Trent Richardson. Their defense is still suspect, but not many teams can score with the Colts.The Ravens have been a surprise in how productive the offense has been behind quarterbacks Joe Flacco coming off a 48-17 bombing of the Tampa Bay Bucs.And even though the Cincinnati Bengals have lost one and tied one in their last two games they are still the team to beat in the AFC North.The current AFC North standing: Bengals 3-1-1, Ravens 4-2, Browns 3-2 and Steelers 3-3.This weeks’ schedule: Steelers home against the Texans, Browns at Jacksonville, Bengals at Indianapolis and the Atlanta Falcons at Baltimore.Projected winners are: Steelers, Browns, Ravens and Bengals.
Submitted by Adrienne CherryZiya Laura of Olympia was recently selected to participate in the 2014 Miss Jr. Pre-Teen Tacoma/Seattle pageant competition that will take place on Saturday, October 11, 2014. Ziya learned of her acceptance into this year’s competition when the pageant announced their selections following interviewing in the local Tacoma/Seattle area. Ziya submitted an application and took part in an interview session that was conducted by this year’s Tacoma/Seattle Pageant Coordinator.Ziya will be competing, for her share of thousands of dollars in prizes and specialty gifts that will be distributed to contestants. Ziya will be competing in the Miss Jr. Pre-Teen division, one of four divisions that will have young ladies ages 7 and 19 competing in modeling routines, which include casual wear and formal wear. Most important, Ziya will display her personality and interviewing skills while interviewing with this year’s Tacoma/Seattle judging panel. Personality is the number one aspect that each contestant is judged on during all phases of competition.If Ziya were to win the title of Miss Jr. Pre-Teen Tacoma/Seattle, she would represent Tacoma/Seattle and the surrounding communities at the National Competition that will take place in Orlando, Florida. Over $30,000.00 in prizes and awards will be presented at the National Competition while each winner enjoys this expense paid trip of five nights and six days in Orlando, Florida.Community businesses, organizations, and private individuals will assist Ziya in participating in this year’s competition by becoming an official sponsor to her. Through sponsorship, each contestant receives all the necessary training, rehearsals, and financial support which will allow Ziya to become a very confident and well-prepared contestant in this year’s Tacoma/Seattle Pageant.Ziya sends her thanks to her local sponsors – Elly Molina, did, inc., McLendons Hardware, and Vision Health. Facebook0Tweet0Pin0